Mechanisms of Cerebral Vascular dysfunction and Neuroinflammation by MMP-Mediated degradation of VeGFr-2 in alcohol ingestion
نویسندگان
چکیده
Received on: December 12, 2011; final version accepted on: February 22, 2012. From the Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE. the online-only data supplement is available with this article at http://atvb .ahajournals .org/lookup/suppl/doi:10 .1161/atVBaHa .112 .247668/-/ dC1 . Correspondence to James Haorah, Laboratory of Neurovascular Oxidative Injury, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198. E-mail [email protected] © 2012 American Heart Association, Inc.
منابع مشابه
The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion.
OBJECTIVE Blood-brain barrier (BBB) dysfunction caused by activation of matrix metalloproteinases (MMPs) is a pathological feature in vascular/neurological disease. We describe the mechanisms of BBB dysfunction and neuroinflammation as a result of MMP-3/9 activation and disruption of vascular endothelial growth factor (VEGF)-A/VEGFR-2 interaction, impairing effective angiogenesis. METHODS AND...
متن کاملP 62: Markers of Neuroinflammation Related to Alzheimer\'s Disease Pathology in the Elderly
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...
متن کاملP101: Neuroinflammation and Cognitive Dysfunction as a Side Effect of Abdominal Surgery
One of the most common postoperative complications is Postoperative cognitive dysfunction (POCD), and it’s usually a geriatric’s disease. Although many studies have done, the exact molecular mechanisms of POCD is still largely unknown; nevertheless, neuroinflammation has been increasingly denoted as one of the core mechanisms for the pathogenesis of POCD. As a hypothesize, surgery-i...
متن کاملP100: A Review of Postoperative Cognitive Dysfunction and Neuroinflammation Processes Induced by Anaesthesia
Although anaesthesia is generally effective, safe and also an indispensable preoperative clinical approach, there is a really growing concern about usage, form of usage and dosage of it. Postoperative cognitive dysfunction (POCD) is one of the common postoperative complications that often affects elderly patients and includes a range of domains, may involve oxidative stress and neuroinflammatio...
متن کامل